Wildland Fire Fighters: Exposure Assessment, Carcinogenic Effects and Risk Management

University of Arizona, Principal Investigator - Jefferey L. Burgess

RELEVANCE

Wildland firefighters are exposed to multiple carcinogens including but not limited to polycyclic aromatic hydrocarbons (PAHs), formaldehyde, and benzene in smoke from wildland and WUI fires. In addition to smoke inhalation, wildland firefighters are exposed to carcinogens absorbed through their skin. Cancer is a leading cause of fire service morbidity and mortality in municipal firefighters, but it has not been possible to conduct an adequately sized epidemiologic study to directly measure cancer rates in wildland firefighters, although based on their exposures we expect increased cancer rates. Since cancer has a long latency period between exposure and disease onset, measurements are needed now that can identify which exposures are causing carcinogenic effects and that can also determine the effectiveness of new interventions on a much shorter time interval.

METHODS

Building on the existing structure of the Fire Fighter Cancer Cohort Study (FFCCS), we will enroll at least 100 wildland new recruits and up to 200 incumbent career and volunteer wildland firefighters across multiple fire departments. Surveys for self-reported cancer risk and occupational exposures and blood for epigenetic analysis of cancer risk will be collected at enrollment for all study participants, and again after 6-18 months in the recruits, evaluating for association with interim wildland and WUI fire exposure. Urine samples will be collected before and after fire exposures selected by the partner fire departments, measuring urinary PAH metabolites to quantify exposures.

ANTICIPATED OUTCOMES

We will identify exposures and measures of increased cancer risk in wildland firefighters, which will be used to inform interventions to reduce exposures.